The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a profound impact on global health, economies, and daily life. One of the most challenging aspects of this virus is its ability to mutate rapidly, leading to the emergence of new variants. These variants can be more contagious, more lethal, or capable of evading the immune system, making it harder to control the spread of the virus. For example, mutations like D614G have been shown to increase the virus’s infectiousness, while others, such as N501Y and E484K, have been linked to increased severity and immune evasion. Understanding these mutations and their effects is crucial for developing effective vaccines, diagnostic tools, and treatments. This study focuses on identifying conserved epitopes—parts of the virus that remain unchanged across mutations—in the SARS-CoV-2 genome isolated in Kenya. By doing so, we aim to contribute to the global effort to combat the pandemic.